send-mail: fatal: chdir /Library/Server/Mail/Data/spool: No such file or directoryTo fix just run in terminal:
sudo mkdir -p /Library/Server/Mail/Data/spool
sudo /usr/sbin/postfix set-permissions
sudo /usr/sbin/postfix start
The solution also fixes an error in 10.8 where the fax service has stopped sending emails after the 10.8 upgrade.
Another Postfix Mac OS X issue solution can be found here: Mac OS, MySQL: No such file or directory (trying to connect via unix:///var/mysql/mysql.sock)